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Stephen Chambers Top-Executive

I left the UK because the US was where scientists were building companies. So that's where I went.
I joined Vertex Pharmaceuticals (NASDAQ:VRTX) as a founding scientist, where I got to see firsthand how great science becomes FDA-approved medicine. From there I co-founded Abpro Therapeutics (NASDAQ:ABP), using synthetic biology to rethink how antibodies are discovered and developed. Along the way I figured out that I loved building companies just as much as I loved the science, maybe more.

There's a pattern to where I've chosen to be. When I arrived in the US, Boston/Cambridge were just starting to become what they are now, a genuine hub for life science entrepreneurship. I was there at the beginning of that. So when the UK started showing the same early signs, it felt like a natural next move. I led SynbiCITE and co-founded the UK's first synthetic biology accelerator, working to give the next generation of scientist-founders a real path forward. Something that hadn't existed when I left.

New York felt the same way. That same early energy, that same sense of something just starting to take shape. As General Partner at SOSV New York, I'm investing in early-stage deep tech founders at the moment when everything is still possible and nothing is guaranteed. It's my favorite stage: raw science, big ambition, everything to prove.

If you're a scientist thinking about starting a company, or a founder navigating that awkward early stage where the idea is solid but the path isn't clear yet, I've lived that journey and I'm genuinely happy to talk.


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Headquarters: New York, New York, United States
Headline: Managing Director & General Partner, SOSV
Followers: 1631
Connections: 1646
Company: SOSV
Skills: Mentoring, Startups, Clinical Development, Protein Expression, Protein Engineering, Monoclonal Antibodies, Business Development, Automation, Design of Experiments (DOE), Technological Innovation, Synthetic Biology, Project Mangement, Investment , Fundraising, Investments, Biochemistry, Biotechnology, Protein Chemistry, Molecular Biology, Drug Discovery, Start-ups, Cell Culture, Lifesciences, Cell Biology, Technology Transfer, Protein Purification, Life Sciences, R&D, Drug Development, Biopharmaceuticals, Pharmaceutical Industry, Purification, Project Management, Entrepreneurship, Consulting, Volunteering, Commercialization, Venture Capital, High Throughput Screening, Biophysics
Experience: Title: Managing Director & General Partner at SOSV NY Company: SOSV Location: New York, United States Start: Mar 2020 End: Present Title: Royal Society Entrepreneur in Residence Company: Imperial College London Location: London, United Kingdom Start: 2019 End: 2021 Title: Co Founder Company: Bio-start Location: London, United Kingdom Start: Aug 2016 End: Jul 2018 Title: CEO Company: SynbiCITE Location: London, United Kingdom Start: 2014 End: 2018 Title: Advisory Board Member Company: London DNA Foundry Location: London, United Kingdom Start: 2014 End: 2018 Title: Co Founder Company: Abpro Location: Lexington, MA, USA Start: 2008 End: 2013 Title: Director of Gene Expression Company: Vertex Pharmaceuticals Location: Cambridge, MA, USA Start: 1990 End: 2007
Education: School: University of Warwick Degree: PhD Field: Molecular Biology Period: School: University of Birmingham Degree: MS Field: Biotechnology Period: School: Bangor University Degree: BS Field: Biochemistry Period:
Publications: The Foundry: The DNA Synthesis and Construction Foundry @ Imperial College (Biochem. Soc. Trans. (2016) 44, 687–688; doi:10.1042/BST20160007 · Jun 15, 2016) Designing experiments for high-throughput protein expression. (Methods in Molecular Biology: High-throughput Protein Expression and Purification, vol 498 (Doyle, S.A., ed.), Humana Press, pp19-29. · Jan 1, 2009) E.coli and insect cell expression, automated purification and quantitative analysis. (Methods in Molecular Biology: Highthroughput Protein Expression and Purification, vol 498 (Doyle, S.A., ed.), Humana Press, pp143-156. · Jan 1, 2009) Freedom of Expression (Freedom of Expression. Drug Discovery and Development, 11 (8): 31-33. · Jan 1, 2008) Development of a protease production platform for structural-based drug design. (Current Protein and Peptide Science. 8: 439-445. · Jan 1, 2007) Screening factors effecting a response in soluble protein expression: a formalized approach using design of experiments. (Analytical Biochemistry. 351: 122-127. · Jan 1, 2006) Development of a high-throughput protein expression strategy. (BioProcessing. 3 (1): 41-45. · Jan 1, 2004) Express Yourself (Drug Discovery Today. 9:475-477. · Jan 1, 2004) Active-site residues of E.coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions (Antimicrobial Agents and Chemotherapy. 47: 1037- 1046 · Jan 1, 2003) High-throughput protein expression for the post-genomic era. (Drug Discovery Today. 7:759-765. · Jan 1, 2002) High-throughput screening for soluble recombinant expressed kinases in E.coli and insect cells. (Protein Expression and Purification. 36:40-47. · Jan 1, 2002) Design and synthesis of amprenavir, a novel HIV protease inhibitor in Protease Inhibitors in AIDS Therapy (vol. 6 (Ogden and Flexner, eds.), Marcel Dekker, pp101-118. · Jan 1, 2000) The structures of caspase-1, -3, -7 and -8 reveal the basis for substrate and inhibitor specificity. (Chemistry and Biology. 7; 423-432. · Jan 1, 2000) My Bibliography ()
Awards: Life Science Power 50: The scientists, entrepreneurs and investors driving New York’s biotech boom | City & State | Jan 2021 Royal Society's Industrial Fellows College | Royal Society | Apr 2019 Fellow of the Royal Society of Biology (FRSB) | Royal Society of Biology of the United Kingdom | Dec 2017
Country: United States