David Botstein (born 8 September 1942) is an American biologist serving as the chief scientific officer of Calico. He served as the director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University from 2003–2013, where he remains an Anthony B. Evnin Professor of Genomics.In 1998, Botstein and his postdoctoral fellow Michael Eisen, together with graduate student Paul Spellman...