1.

Lloyds Banking Group 1/1/2009

2.

M Ventures 2009-01-01

3.

MassChallenge 2009-06-01

4.

MedHoldings Undisclosed

5.

Michael J. Fox Foundation 2000-01-01

6.

MP Healthcare Venture Management 2006-01-01

7.

Natixis 2006

8.

Neomed Management 1997-01-01

9.

Nestlé Health Science 2011

10.

Nomura Holdings

11.

Novartis 1996-03-22

12.

Novartis Venture Fund 1996-01-01

13.

Novo Holdings 1999-01-01

14.

Odey Asset Management 1991-01-01

15.

Omega Funds 2004-01-01

16.

Palmarium Undisclosed

17.

PMV Tina Fund 2012

18.

PPF Group 1991

19.

Preon Capital Partners Jan 1, 2014

20.

Quest Capital Management 1987

21.

Redalpine Venture Partners 2007

22.

Royal Bank of Canada 1864

23.

Seroba Life Sciences 2009-01-01

24.

Sofinnova Partners 1972-01-01

25.

SR One 1985-01-01