{ "FullStudy":{ "Rank":217867, "Study":{ "ProtocolSection":{ "IdentificationModule":{ "NCTId":"NCT01515800", "OrgStudyIdInfo":{ "OrgStudyId":"CDR0000723653" }, "SecondaryIdInfoList":{ "SecondaryIdInfo":[ { "SecondaryId":"S1105", "SecondaryIdType":"Other Identifier", "SecondaryIdDomain":"SWOG" },{ "SecondaryId":"U10CA037429", "SecondaryIdType":"U.S. NIH Grant/Contract", "SecondaryIdLink":"https://projectreporter.nih.gov/reporterapi.cfm?PROJECTNUM=U10CA037429&Fy=all" } ] }, "Organization":{ "OrgFullName":"Southwest Oncology Group", "OrgClass":"NETWORK" }, "BriefTitle":"S1105: Text-Messaging Intervention to Reduce Early Discontinuation of AI Therapy in Women With Early-Stage Breast Cancer", "OfficialTitle":"S1105, Randomized Trial Of Text-Messaging Intervention To Reduce Early Discontinuation Of Adjuvant Aromatase Inhibitor Therapy In Women With Early Stage Breast Cancer" }, "StatusModule":{ "StatusVerifiedDate":"March 2018", "OverallStatus":"Completed", "ExpandedAccessInfo":{ "HasExpandedAccess":"No" }, "StartDateStruct":{ "StartDate":"May 2012" }, "PrimaryCompletionDateStruct":{ "PrimaryCompletionDate":"January 2018", "PrimaryCompletionDateType":"Actual" }, "CompletionDateStruct":{ "CompletionDate":"February 2018", "CompletionDateType":"Actual" }, "StudyFirstSubmitDate":"January 21, 2012", "StudyFirstSubmitQCDate":"January 21, 2012", "StudyFirstPostDateStruct":{ "StudyFirstPostDate":"January 24, 2012", "StudyFirstPostDateType":"Estimate" }, "LastUpdateSubmitDate":"March 6, 2018", "LastUpdatePostDateStruct":{ "LastUpdatePostDate":"March 8, 2018", "LastUpdatePostDateType":"Actual" } }, "SponsorCollaboratorsModule":{ "ResponsibleParty":{ "ResponsiblePartyType":"Sponsor" }, "LeadSponsor":{ "LeadSponsorName":"Southwest Oncology Group", "LeadSponsorClass":"NETWORK" }, "CollaboratorList":{ "Collaborator":[ { "CollaboratorName":"National Cancer Institute (NCI)", "CollaboratorClass":"NIH" } ] } }, "OversightModule":{ "OversightHasDMC":"Yes" }, "DescriptionModule":{ "BriefSummary":"RATIONALE: Measuring how text-message affects treatment compliance in women with breast cancer may help doctors plan the best treatment.\n\nPURPOSE: This randomized trial studies how well text-message works in reducing early discontinuation of aromatase inhibitor therapy in patients with early-stage breast cancer who underwent breast surgery.", "DetailedDescription":"OBJECTIVES:\n\nPrimary\n\nTo determine the efficacy of a reminder message, sent by text message to mobile phones twice weekly, to improve adherence to adjuvant aromatase inhibitor (AI) therapy as determined by urinary AI levels in women with early-stage hormone-sensitive breast cancer versus usual care.\n\nSecondary\n\nTo compare the effect of a reminder message sent twice weekly to mobile phones as compared to usual care to improve adherence to adjuvant AI therapy according to self-report.\nTo explore the efficacy of the text message intervention for reducing early discontinuation as compared to usual care at 12, 24, and 36 months of adjuvant AI therapy in subgroups of breast cancer patients as defined by age group, stage, year of therapy, education, race/ethnicity, teaching hospital versus community hospital, AI-related side effects (as determined by serial questionnaires), insurance status, and prescription co-pay status.\nTo explore the reasons for early discontinuation of AI therapy in those who do discontinue in the intervention and control group by querying quality of life as assessed by the Functional Assessment of Cancer Therapy-Endocrine Subscales (FACT-ES) and symptoms and other issues related to hormonal therapy at each follow-up visit, using the Brief Pain Inventory (BPI-SF), and at annual visits the Beliefs about Medicine Questionnaire (BQM) and the Treatment Satisfaction Questionnaire for Medication (TSQM).\nTo conduct a sensitivity analysis assessing time to last evidence of adherence.\n\nOUTLINE: This is a multicenter study. Patients are stratified according to length of time on aromatase inhibitor (AI) (< 12 months vs 12-24 months), and type of AI (anastrozole vs letrozole vs exemestane). Patients are randomized to 1 of 2 intervention arms.\n\nArm I: Patients undergo a text message education checklist involving confirmation of cellular telephone capability to receive text messages, how to retrieve and read messages, including a confirmation evaluation, at baseline and at any time a patient obtains a new cellular telephone. Patients then receive a text message twice a week at 8 o'clock in the morning (for each time zone) for up to 3 years.\nArm II: Patients receive standard follow-up care. Patients undergo urine sample collection at baseline and periodically during study for aromatase inhibitor level analysis and future translational studies.\n\nPatients complete the Functional Assessment of Cancer Therapy-Endocrine Subscales (FACT-ES), the Brief Pain Inventory (BPI-SF), Beliefs about Medicine Questionnaire (BQM), and the Treatment Satisfaction Questionnaire for Medication (TSQM) questionnaires at baseline and periodically during study. Patients in arm I also complete the Cell Phone and Text Messaging Use Questionnaire at baseline and periodically during study.\n\nIn both arms, patients are followed up every 3 months for up to 3 years from registration." }, "ConditionsModule":{ "ConditionList":{ "Condition":[ "Breast Cancer" ] }, "KeywordList":{ "Keyword":[ "estrogen receptor-positive breast cancer", "progesterone receptor-positive breast cancer", "stage IA breast cancer", "stage IB breast cancer", "stage II breast cancer", "stage IIIA breast cancer" ] } }, "DesignModule":{ "StudyType":"Interventional", "PhaseList":{ "Phase":[ "Not Applicable" ] }, "DesignInfo":{ "DesignAllocation":"Randomized", "DesignInterventionModel":"Parallel Assignment", "DesignPrimaryPurpose":"Other", "DesignMaskingInfo":{ "DesignMasking":"None (Open Label)" } }, "EnrollmentInfo":{ "EnrollmentCount":"724", "EnrollmentType":"Actual" } }, "ArmsInterventionsModule":{ "ArmGroupList":{ "ArmGroup":[ { "ArmGroupLabel":"Text message reminder", "ArmGroupType":"Experimental", "ArmGroupDescription":"Patients undergo a text message education checklist involving confirmation of cellular telephone capability to receive text messages, how to retrieve and read messages, including a confirmation evaluation, at baseline and at any time a patient obtains a new cellular telephone. Patients then receive a text message twice a week at 8 o'clock in the morning (for each time zone) for up to 3 years. Additionally, patients receive standard follow-up care.", "ArmGroupInterventionList":{ "ArmGroupInterventionName":[ "Behavioral: Text message reminder" ] } },{ "ArmGroupLabel":"No text message reminder", "ArmGroupType":"No Intervention", "ArmGroupDescription":"Patients receive standard follow-up care." } ] }, "InterventionList":{ "Intervention":[ { "InterventionType":"Behavioral", "InterventionName":"Text message reminder", "InterventionDescription":"Receive text message", "InterventionArmGroupLabelList":{ "InterventionArmGroupLabel":[ "Text message reminder" ] } } ] } }, "OutcomesModule":{ "PrimaryOutcomeList":{ "PrimaryOutcome":[ { "PrimaryOutcomeMeasure":"Time to first evidence of adherence failure (discontinuation)", "PrimaryOutcomeTimeFrame":"Every 3 months after randomization" } ] }, "SecondaryOutcomeList":{ "SecondaryOutcome":[ { "SecondaryOutcomeMeasure":"Adherence effect of text message compared to usual care using the patient self-report responses to AI Usage form", "SecondaryOutcomeTimeFrame":"Every 3 months after randomization" },{ "SecondaryOutcomeMeasure":"Relationship between randomized arm and various participant, site and health insurance characteristics", "SecondaryOutcomeDescription":"Relationship between randomized arm and the following factors: age group, stage, years of therapy, education, race/ethnicity, teaching hospital versus community hospital, AI-related side effects, insurance status, and prescription co-pay status.", "SecondaryOutcomeTimeFrame":"Every 3 months after randomization" },{ "SecondaryOutcomeMeasure":"Reasons for early discontinuation of AI therapy among intervention arm and control arm as assessed by quality-of-life questionnaires", "SecondaryOutcomeTimeFrame":"Every 3 months after randomization" },{ "SecondaryOutcomeMeasure":"Time to last evidence of adherence", "SecondaryOutcomeTimeFrame":"Every 3 months after randomization" } ] } }, "EligibilityModule":{ "EligibilityCriteria":"DISEASE CHARACTERISTICS:\n\nPatients must be women with a diagnosis of histologically confirmed, primary invasive, hormone-sensitive (estrogen receptor-positive [ER]/progesterone receptor [PR]-positive) adenocarcinoma of the breast (Stage I, II or III) with no evidence of recurrent or metastatic disease (M0)\nPatients must have a mobile phone that can receive text messages and must currently use or be willing to learn to use text messaging\n\nPATIENT CHARACTERISTICS:\n\nPatients must be postmenopausal, as defined by at least one of the following:\n\n≥ 12 months since the last menstrual period\nPrior bilateral oophorectomy\nPrevious hysterectomy with one or both ovaries left in place (or previous hysterectomy in which documentation of bilateral oophorectomy is unavailable) AND follicle-stimulating hormone (FSH) values consistent with the institutional normal values for the postmenopausal state; FSH levels must be obtained within 28 days prior to registration\nPatients must be willing to provide urine specimen to test for the presence of aromatase inhibitor within 28 days of randomization and at each 3-month clinic visit for 3 years\nPatients must have the ability to speak and read English\nPatients must have a Zubrod performance status of 0 - 2\nNo other prior malignancy (i.e., other than as noted on disease characteristics) is allowed except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for > 5 years\nPatients are allowed to participate in another clinical trial as long as it does not interfere with daily intake of aromatase-inhibitor therapy\n\nPRIOR CONCURRENT THERAPY:\n\nPatients must be post adjuvant chemotherapy (if to be utilized) and primary curative surgery and must have recovered from all side-effects of the surgery\n\nTrastuzumab (Herceptin) given alone after cytotoxic chemotherapy is considered adjuvant chemotherapy; patients would be eligible upon completion of Herceptin as long as the other eligibility criteria are met\nPatients must be currently taking an aromatase inhibitor (AI), have completed at least one month of AI therapy, be within the first 5 years of planned AI therapy, and have at least 3 years remaining before completion of planned AI therapy\n\nExclusion criteria: Insufficient evidence of post-menopausal status; metastatic or recurrent disease; currently receiving chemotherapy.", "HealthyVolunteers":"No", "Gender":"Female", "MinimumAge":"18 Years", "MaximumAge":"120 Years", "StdAgeList":{ "StdAge":[ "Adult", "Older Adult" ] } }, "ContactsLocationsModule":{ "OverallOfficialList":{ "OverallOfficial":[ { "OverallOfficialName":"Alfred I. Neugut, MD, PhD", "OverallOfficialAffiliation":"Herbert Irving Comprehensive Cancer Center", "OverallOfficialRole":"Principal Investigator" } ] }, "LocationList":{ "Location":[ { "LocationFacility":"Alaska Regional Hospital Cancer Center", "LocationCity":"Anchorage", "LocationState":"Alaska", "LocationZip":"99508", "LocationCountry":"United States" },{ "LocationFacility":"Hembree Mercy Cancer Center at St. Edward Mercy Medical Center", "LocationCity":"Fort Smith", "LocationState":"Arkansas", "LocationZip":"72903", "LocationCountry":"United States" },{ "LocationFacility":"Arkansas Cancer Research Center at University of Arkansas for Medical Sciences", "LocationCity":"Little Rock", "LocationState":"Arkansas", "LocationZip":"72205", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente - Deer Valley", "LocationCity":"Antioch", "LocationState":"California", "LocationZip":"94531", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente - Fremont", "LocationCity":"Fremont", "LocationState":"California", "LocationZip":"94538", "LocationCountry":"United States" },{ "LocationFacility":"California Cancer Center - Woodward Park Office", "LocationCity":"Fresno", "LocationState":"California", "LocationZip":"93720", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Fresno Medical Center", "LocationCity":"Fresno", "LocationState":"California", "LocationZip":"93720", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Hayward", "LocationCity":"Hayward", "LocationState":"California", "LocationZip":"94545", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Oakland", "LocationCity":"Oakland", "LocationState":"California", "LocationZip":"94611", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Redwood City", "LocationCity":"Redwood City", "LocationState":"California", "LocationZip":"94063", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Richmond", "LocationCity":"Richmond", "LocationState":"California", "LocationZip":"94801", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Roseville", "LocationCity":"Roseville", "LocationState":"California", "LocationZip":"95661", "LocationCountry":"United States" },{ "LocationFacility":"South Sacramento Kaiser-Permanente Medical Center", "LocationCity":"Sacramento", "LocationState":"California", "LocationZip":"95823", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Sacramento", "LocationCity":"Sacramento", "LocationState":"California", "LocationZip":"95825", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - San Francisco Geary Campus", "LocationCity":"San Francisco", "LocationState":"California", "LocationZip":"94115", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Santa Teresa", "LocationCity":"San Jose", "LocationState":"California", "LocationZip":"95119", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Foundation Hospital - San Rafael", "LocationCity":"San Rafael", "LocationState":"California", "LocationZip":"94903", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Santa Clara Kiely Campus", "LocationCity":"Santa Clara", "LocationState":"California", "LocationZip":"95051", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Santa Rosa", "LocationCity":"Santa Rosa", "LocationState":"California", "LocationZip":"95403", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - South San Francisco", "LocationCity":"South San Francisco", "LocationState":"California", "LocationZip":"94080", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Facility - Stockton", "LocationCity":"Stockton", "LocationState":"California", "LocationZip":"95210", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Vacaville", "LocationCity":"Vacaville", "LocationState":"California", "LocationZip":"95688", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Vallejo", "LocationCity":"Vallejo", "LocationState":"California", "LocationZip":"94589", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente Medical Center - Walnut Creek", "LocationCity":"Walnut Creek", "LocationState":"California", "LocationZip":"94596", "LocationCountry":"United States" },{ "LocationFacility":"Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center", "LocationCity":"Hartford", "LocationState":"Connecticut", "LocationZip":"06105", "LocationCountry":"United States" },{ "LocationFacility":"Kapiolani Medical Center at Pali Momi", "LocationCity":"'Aiea", "LocationState":"Hawaii", "LocationZip":"96701", "LocationCountry":"United States" },{ "LocationFacility":"Oncare Hawaii, Incorporated - Pali Momi", "LocationCity":"'Aiea", "LocationState":"Hawaii", "LocationZip":"96701", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Research Center of Hawaii", "LocationCity":"Honolulu", "LocationState":"Hawaii", "LocationZip":"96813", "LocationCountry":"United States" },{ "LocationFacility":"OnCare Hawaii, Incorporated - Lusitana", "LocationCity":"Honolulu", "LocationState":"Hawaii", "LocationZip":"96813", "LocationCountry":"United States" },{ "LocationFacility":"Queen's Cancer Institute at Queen's Medical Center", "LocationCity":"Honolulu", "LocationState":"Hawaii", "LocationZip":"96813", "LocationCountry":"United States" },{ "LocationFacility":"Straub Clinic and Hospital, Incorporated", "LocationCity":"Honolulu", "LocationState":"Hawaii", "LocationZip":"96813", "LocationCountry":"United States" },{ "LocationFacility":"OnCare Hawaii, Incorporated - Kuakini", "LocationCity":"Honolulu", "LocationState":"Hawaii", "LocationZip":"96817-3169", "LocationCountry":"United States" },{ "LocationFacility":"Kuakini Medical Center", "LocationCity":"Honolulu", "LocationState":"Hawaii", "LocationZip":"96817", "LocationCountry":"United States" },{ "LocationFacility":"Kaiser Permanente - Moanalua Medical Center and Clinic", "LocationCity":"Honolulu", "LocationState":"Hawaii", "LocationZip":"96819", "LocationCountry":"United States" },{ "LocationFacility":"Kapiolani Medical Center for Women and Children", "LocationCity":"Honolulu", "LocationState":"Hawaii", "LocationZip":"96826", "LocationCountry":"United States" },{ "LocationFacility":"Tripler Army Medical Center", "LocationCity":"Honolulu", "LocationState":"Hawaii", "LocationZip":"96859", "LocationCountry":"United States" },{ "LocationFacility":"Castle Medical Center", "LocationCity":"Kailua", "LocationState":"Hawaii", "LocationZip":"96734", "LocationCountry":"United States" },{ "LocationFacility":"Kauai Medical Clinic", "LocationCity":"Lihue", "LocationState":"Hawaii", "LocationZip":"96766", "LocationCountry":"United States" },{ "LocationFacility":"Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center", "LocationCity":"Boise", "LocationState":"Idaho", "LocationZip":"83706", "LocationCountry":"United States" },{ "LocationFacility":"Decatur Memorial Hospital Cancer Care Institute", "LocationCity":"Decatur", "LocationState":"Illinois", "LocationZip":"62526", "LocationCountry":"United States" },{ "LocationFacility":"Sherman Hospital", "LocationCity":"Elgin", "LocationState":"Illinois", "LocationZip":"60123", "LocationCountry":"United States" },{ "LocationFacility":"Cardinal Bernardin Cancer Center at Loyola University Medical Center", "LocationCity":"Maywood", "LocationState":"Illinois", "LocationZip":"60153", "LocationCountry":"United States" },{ "LocationFacility":"Good Samaritan Regional Health Center", "LocationCity":"Mount Vernon", "LocationState":"Illinois", "LocationZip":"62864", "LocationCountry":"United States" },{ "LocationFacility":"Regional Cancer Center at Memorial Medical Center", "LocationCity":"Springfield", "LocationState":"Illinois", "LocationZip":"62781-0001", "LocationCountry":"United States" },{ "LocationFacility":"St. Francis Hospital and Health Centers - Beech Grove Campus", "LocationCity":"Beech Grove", "LocationState":"Indiana", "LocationZip":"46107", "LocationCountry":"United States" },{ "LocationFacility":"Reid Hospital & Health Care Services", "LocationCity":"Richmond", "LocationState":"Indiana", "LocationZip":"47374", "LocationCountry":"United States" },{ "LocationFacility":"Genesis Regional Cancer Center at Genesis Medical Center", "LocationCity":"Davenport", "LocationState":"Iowa", "LocationZip":"52803", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Chanute", "LocationCity":"Chanute", "LocationState":"Kansas", "LocationZip":"66720", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Dodge City", "LocationCity":"Dodge City", "LocationState":"Kansas", "LocationZip":"67801", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas - Fort Scott", "LocationCity":"Fort Scott", "LocationState":"Kansas", "LocationZip":"66701", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas-Independence", "LocationCity":"Independence", "LocationState":"Kansas", "LocationZip":"67301", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Kingman", "LocationCity":"Kingman", "LocationState":"Kansas", "LocationZip":"67068", "LocationCountry":"United States" },{ "LocationFacility":"Lawrence Memorial Hospital", "LocationCity":"Lawrence", "LocationState":"Kansas", "LocationZip":"66044", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Liberal", "LocationCity":"Liberal", "LocationState":"Kansas", "LocationZip":"67901", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Newton", "LocationCity":"Newton", "LocationState":"Kansas", "LocationZip":"67114", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Parsons", "LocationCity":"Parsons", "LocationState":"Kansas", "LocationZip":"67357", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Pratt", "LocationCity":"Pratt", "LocationState":"Kansas", "LocationZip":"67124", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Salina", "LocationCity":"Salina", "LocationState":"Kansas", "LocationZip":"67401", "LocationCountry":"United States" },{ "LocationFacility":"Cotton-O'Neil Cancer Center", "LocationCity":"Topeka", "LocationState":"Kansas", "LocationZip":"66606", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Wellington", "LocationCity":"Wellington", "LocationState":"Kansas", "LocationZip":"67152", "LocationCountry":"United States" },{ "LocationFacility":"Associates in Womens Health, PA - North Review", "LocationCity":"Wichita", "LocationState":"Kansas", "LocationZip":"67208", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Medical Arts Tower", "LocationCity":"Wichita", "LocationState":"Kansas", "LocationZip":"67208", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Wichita", "LocationCity":"Wichita", "LocationState":"Kansas", "LocationZip":"67214", "LocationCountry":"United States" },{ "LocationFacility":"CCOP - Wichita", "LocationCity":"Wichita", "LocationState":"Kansas", "LocationZip":"67214", "LocationCountry":"United States" },{ "LocationFacility":"Via Christi Cancer Center at Via Christi Regional Medical Center", "LocationCity":"Wichita", "LocationState":"Kansas", "LocationZip":"67214", "LocationCountry":"United States" },{ "LocationFacility":"Cancer Center of Kansas, PA - Winfield", "LocationCity":"Winfield", "LocationState":"Kansas", "LocationZip":"67156", "LocationCountry":"United States" },{ "LocationFacility":"Highland Clinic", "LocationCity":"Shreveport", "LocationState":"Louisiana", "LocationZip":"71105", "LocationCountry":"United States" },{ "LocationFacility":"Feist-Weiller Cancer Center at Louisiana State University Health Sciences", "LocationCity":"Shreveport", "LocationState":"Louisiana", "LocationZip":"71130-3932", "LocationCountry":"United States" },{ "LocationFacility":"Boston University Cancer Research Center", "LocationCity":"Boston", "LocationState":"Massachusetts", "LocationZip":"02118", "LocationCountry":"United States" },{ "LocationFacility":"Saint Joseph Mercy Cancer Center", "LocationCity":"Ann Arbor", "LocationState":"Michigan", "LocationZip":"48106-0995", "LocationCountry":"United States" },{ "LocationFacility":"CCOP - Michigan Cancer Research Consortium", "LocationCity":"Ann Arbor", "LocationState":"Michigan", "LocationZip":"48106", "LocationCountry":"United States" },{ "LocationFacility":"Battle Creek Health System Cancer Care Center", "LocationCity":"Battle Creek", "LocationState":"Michigan", "LocationZip":"49017", "LocationCountry":"United States" },{ "LocationFacility":"Mecosta County Medical Center", "LocationCity":"Big Rapids", "LocationState":"Michigan", "LocationZip":"49307", "LocationCountry":"United States" },{ "LocationFacility":"Oakwood Cancer Center at Oakwood Hospital and Medical Center", "LocationCity":"Dearborn", "LocationState":"Michigan", "LocationZip":"48123-2500", "LocationCountry":"United States" },{ "LocationFacility":"Josephine Ford Cancer Center at Henry Ford Hospital", "LocationCity":"Detroit", "LocationState":"Michigan", "LocationZip":"48202", "LocationCountry":"United States" },{ "LocationFacility":"Genesys Hurley Cancer Institute", "LocationCity":"Flint", "LocationState":"Michigan", "LocationZip":"48503", "LocationCountry":"United States" },{ "LocationFacility":"Hurley Medical Center", "LocationCity":"Flint", "LocationState":"Michigan", "LocationZip":"48503", "LocationCountry":"United States" },{ "LocationFacility":"Butterworth Hospital at Spectrum Health", "LocationCity":"Grand Rapids", "LocationState":"Michigan", "LocationZip":"49503", "LocationCountry":"United States" },{ "LocationFacility":"CCOP - Grand Rapids", "LocationCity":"Grand Rapids", "LocationState":"Michigan", "LocationZip":"49503", "LocationCountry":"United States" },{ "LocationFacility":"Lacks Cancer Center at Saint Mary's Health Care", "LocationCity":"Grand Rapids", "LocationState":"Michigan", "LocationZip":"49503", "LocationCountry":"United States" },{ "LocationFacility":"Van Elslander Cancer Center at St. John Hospital and Medical Center", "LocationCity":"Grosse Pointe Woods", "LocationState":"Michigan", "LocationZip":"48236", "LocationCountry":"United States" },{ "LocationFacility":"Foote Memorial Hospital", "LocationCity":"Jackson", "LocationState":"Michigan", "LocationZip":"49201", "LocationCountry":"United States" },{ "LocationFacility":"Sparrow Regional Cancer Center", "LocationCity":"Lansing", "LocationState":"Michigan", "LocationZip":"48912-1811", "LocationCountry":"United States" },{ "LocationFacility":"St. Mary Mercy Hospital", "LocationCity":"Livonia", "LocationState":"Michigan", "LocationZip":"48154", "LocationCountry":"United States" },{ "LocationFacility":"Mercy General Health Partners", "LocationCity":"Muskegon", "LocationState":"Michigan", "LocationZip":"49444", "LocationCountry":"United States" },{ "LocationFacility":"St. Joseph Mercy Oakland", "LocationCity":"Pontiac", "LocationState":"Michigan", "LocationZip":"48341-2985", "LocationCountry":"United States" },{ "LocationFacility":"Mercy Regional Cancer Center at Mercy Hospital", "LocationCity":"Port Huron", "LocationState":"Michigan", "LocationZip":"48060", "LocationCountry":"United States" },{ "LocationFacility":"Spectrum Health Reed City Hospital", "LocationCity":"Reed City", "LocationState":"Michigan", "LocationZip":"49677", "LocationCountry":"United States" },{ "LocationFacility":"Seton Cancer Institute at Saint Mary's - 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