{
  "FullStudy":{
    "Rank":218198,
    "Study":{
      "ProtocolSection":{
        "IdentificationModule":{
          "NCTId":"NCT01511458",
          "OrgStudyIdInfo":{
            "OrgStudyId":"TD007"
          },
          "Organization":{
            "OrgFullName":"Roche Sequencing Solutions",
            "OrgClass":"INDUSTRY"
          },
          "BriefTitle":"Non-invasive Chromosomal Examination of Trisomy Study",
          "OfficialTitle":"Non-invasive Chromosomal Examination of Trisomy",
          "Acronym":"NEXT"
        },
        "StatusModule":{
          "StatusVerifiedDate":"July 2014",
          "OverallStatus":"Completed",
          "ExpandedAccessInfo":{
            "HasExpandedAccess":"No"
          },
          "StartDateStruct":{
            "StartDate":"March 2012"
          },
          "PrimaryCompletionDateStruct":{
            "PrimaryCompletionDate":"November 2013",
            "PrimaryCompletionDateType":"Actual"
          },
          "CompletionDateStruct":{
            "CompletionDate":"May 2014",
            "CompletionDateType":"Actual"
          },
          "StudyFirstSubmitDate":"January 13, 2012",
          "StudyFirstSubmitQCDate":"January 17, 2012",
          "StudyFirstPostDateStruct":{
            "StudyFirstPostDate":"January 18, 2012",
            "StudyFirstPostDateType":"Estimate"
          },
          "LastUpdateSubmitDate":"July 11, 2014",
          "LastUpdatePostDateStruct":{
            "LastUpdatePostDate":"July 14, 2014",
            "LastUpdatePostDateType":"Estimate"
          }
        },
        "SponsorCollaboratorsModule":{
          "ResponsibleParty":{
            "ResponsiblePartyType":"Sponsor"
          },
          "LeadSponsor":{
            "LeadSponsorName":"Roche Sequencing Solutions",
            "LeadSponsorClass":"INDUSTRY"
          },
          "CollaboratorList":{
            "Collaborator":[
              {
                "CollaboratorName":"Perinatal Quality Foundation: Nuchal Translucency Quality Review",
                "CollaboratorClass":"UNKNOWN"
              }
            ]
          }
        },
        "OversightModule":{
          "OversightHasDMC":"Yes"
        },
        "DescriptionModule":{
          "BriefSummary":"The purpose of this blinded, multi-center, prospective, case-controlled study is to compare the Ariosa Harmony™ Prenatal Test for trisomy 21 detection with a standard first-trimester prenatal screening test consisting of serum screening (PAPP-A,free beta-hCG [β-hCG] or total hCG) and a nuchal translucency (NT) measurement (i.e. combined first trimester screening) in a general screened population.\n\nThe performance characteristics of these two test modalities will be assessed relative to the clinical reference standard of genetic analysis of the fetus or phenotypic characterization and genetic analysis of the newborn."
        },
        "ConditionsModule":{
          "ConditionList":{
            "Condition":[
              "Trisomy 21"
            ]
          },
          "KeywordList":{
            "Keyword":[
              "Pregnancy",
              "Fetal aneuploidy",
              "Trisomy 21",
              "Down Syndrome",
              "Prenatal screening",
              "Non-invasive prenatal testing",
              "First trimester",
              "Combined screening",
              "Nuchal translucency",
              "PAPP-A",
              "hCG",
              "cell free DNA",
              "cf DNA",
              "DNA",
              "Performance characteristics of non-invasive first trimester screening",
              "Harmony Prenatal Test"
            ]
          }
        },
        "DesignModule":{
          "StudyType":"Observational",
          "PatientRegistry":"No",
          "DesignInfo":{
            "DesignTimePerspectiveList":{
              "DesignTimePerspective":[
                "Prospective"
              ]
            }
          },
          "EnrollmentInfo":{
            "EnrollmentCount":"18955",
            "EnrollmentType":"Actual"
          }
        },
        "ArmsInterventionsModule":{
          "ArmGroupList":{
            "ArmGroup":[
              {
                "ArmGroupLabel":"Case",
                "ArmGroupDescription":"Patient with a trisomy 21 pregnancy confirmed by genetic testing."
              },{
                "ArmGroupLabel":"Control",
                "ArmGroupDescription":"Patients without a trisomy 21 pregnancy confirmed by either genetic testing or a normal newborn phenotype."
              }
            ]
          }
        },
        "OutcomesModule":{
          "PrimaryOutcomeList":{
            "PrimaryOutcome":[
              {
                "PrimaryOutcomeMeasure":"Difference in sensitivity and specificity of Ariosa Harmony™ Prenatal Test (AUCt) and combined first-trimester screening for detection of T21.",
                "PrimaryOutcomeTimeFrame":"Enrollment to delivery"
              }
            ]
          }
        },
        "EligibilityModule":{
          "EligibilityCriteria":"Inclusion Criteria:\n\nSubject is at least 18 years old and can provide informed consent.\nSubject is planning a hospital delivery.\nSubject has a singleton pregnancy with a documented gestational age between 10 weeks, 0 days, and 14 weeks, 2 days, inclusive, at the time of the study blood sample collection.\nSubject is planning to undergo combined first trimester prenatal screening that includes NT measurement, and when indicated, serum screening with total or free β-hCG and PAPP-A.\n\nExclusion Criteria:\n\nSubject has known aneuploidy.\nSubject has active or history of malignancy requiring major surgery and/or systemic chemotherapy.\nSubject has a twin demise at any gestational age. Twin demise includes any reductions, spontaneous or elective, after sonographic identification of a second (or more) gestational sac. Any clinical, sonographic, or other testing that suggests twin demise would serve as an exclusion criterion.",
          "HealthyVolunteers":"No",
          "Gender":"Female",
          "MinimumAge":"18 Years",
          "MaximumAge":"60 Years",
          "StdAgeList":{
            "StdAge":[
              "Adult"
            ]
          },
          "StudyPopulation":"Pregnant women presenting for combined first trimester screening as part of routine prenatal care",
          "SamplingMethod":"Non-Probability Sample"
        },
        "ContactsLocationsModule":{
          "OverallOfficialList":{
            "OverallOfficial":[
              {
                "OverallOfficialName":"Mary E. Norton, MD",
                "OverallOfficialAffiliation":"Stanford University",
                "OverallOfficialRole":"Principal Investigator"
              },{
                "OverallOfficialName":"Ronald Wapner, MD",
                "OverallOfficialAffiliation":"Columbia University",
                "OverallOfficialRole":"Principal Investigator"
              }
            ]
          },
          "LocationList":{
            "Location":[
              {
                "LocationFacility":"Tucson Medical Center",
                "LocationCity":"Tucson",
                "LocationState":"Arizona",
                "LocationZip":"85712",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"East Bay Perinatal Associates",
                "LocationCity":"Oakland",
                "LocationState":"California",
                "LocationZip":"94609",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Stanford University",
                "LocationCity":"Palo Alto",
                "LocationState":"California",
                "LocationZip":"94305-5317",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Perinatal Diagnostic Center",
                "LocationCity":"Riverside",
                "LocationState":"California",
                "LocationZip":"92501",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"University of California San Diego",
                "LocationCity":"San Diego",
                "LocationState":"California",
                "LocationZip":"92037-1300",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"California Pacific Medical Center",
                "LocationCity":"San Francisco",
                "LocationState":"California",
                "LocationZip":"94118",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"University of California San Francisco",
                "LocationCity":"San Francisco",
                "LocationState":"California",
                "LocationZip":"94143",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"The Institute of Prenatal Diagnosis and Reproductive Medicine",
                "LocationCity":"San Gabriel",
                "LocationState":"California",
                "LocationZip":"91776",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Christiana Care Health System",
                "LocationCity":"Newark",
                "LocationState":"Delaware",
                "LocationZip":"19718",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Altus Research",
                "LocationCity":"Lake Worth",
                "LocationState":"Florida",
                "LocationZip":"33461",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Fetal Diagnostic Institute of the Pacific",
                "LocationCity":"Honolulu",
                "LocationState":"Hawaii",
                "LocationZip":"96814",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Northshore University Health System",
                "LocationCity":"Evanston",
                "LocationState":"Illinois",
                "LocationZip":"60201",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Norton Healthcare",
                "LocationCity":"Louisville",
                "LocationState":"Kentucky",
                "LocationZip":"40202",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Brigham and Women's Hospital - Center for Fetal Medicine and Prenatal Genetics",
                "LocationCity":"Boston",
                "LocationState":"Massachusetts",
                "LocationZip":"02115",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Minnesota Perinatal Associates",
                "LocationCity":"Minneapolis",
                "LocationState":"Minnesota",
                "LocationZip":"55407",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Robert Wood Johnson School of Medicine",
                "LocationCity":"New Brunswick",
                "LocationState":"New Jersey",
                "LocationZip":"08901",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"St. Peters University Medical Center",
                "LocationCity":"New Brunswick",
                "LocationState":"New Jersey",
                "LocationZip":"08901",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Columbia University",
                "LocationCity":"New York",
                "LocationState":"New York",
                "LocationZip":"10032",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Duke University Medical Center",
                "LocationCity":"Durham",
                "LocationState":"North Carolina",
                "LocationZip":"27710",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Northwest Perinatal Center",
                "LocationCity":"Portland",
                "LocationState":"Oregon",
                "LocationZip":"97225",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Oregon Health Sciences University",
                "LocationCity":"Portland",
                "LocationState":"Oregon",
                "LocationZip":"97239",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Abington Memorial Hospital",
                "LocationCity":"Abington",
                "LocationState":"Pennsylvania",
                "LocationZip":"19001",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Thomas Jefferson Univeristy Hospital",
                "LocationCity":"Philadelphia",
                "LocationState":"Pennsylvania",
                "LocationZip":"19107",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Women's Health Care Group of Pennsylvania",
                "LocationCity":"Wynnewood",
                "LocationState":"Pennsylvania",
                "LocationZip":"19096",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Partners in Obstetrics and Gynecology",
                "LocationCity":"Pawtucket",
                "LocationState":"Rhode Island",
                "LocationZip":"02860",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"Medical College of Wisconsin",
                "LocationCity":"Milwaukee",
                "LocationState":"Wisconsin",
                "LocationZip":"53226",
                "LocationCountry":"United States"
              },{
                "LocationFacility":"University Hospitals Leuven",
                "LocationCity":"Leuven",
                "LocationCountry":"Belgium"
              },{
                "LocationFacility":"Early Risk Assessment Program - University of Alberta",
                "LocationCity":"Calgary",
                "LocationState":"Alberta",
                "LocationZip":"T2N 4N1",
                "LocationCountry":"Canada"
              },{
                "LocationFacility":"Ottawa Hospital and Research Institute",
                "LocationCity":"Ottawa",
                "LocationState":"Ontario",
                "LocationZip":"ON1Kh8L6",
                "LocationCountry":"Canada"
              },{
                "LocationFacility":"Mount Sinai University",
                "LocationCity":"Toronto",
                "LocationState":"Ontario",
                "LocationZip":"M5G 1X5",
                "LocationCountry":"Canada"
              },{
                "LocationFacility":"University of Toronto",
                "LocationCity":"Toronto",
                "LocationState":"Ontario",
                "LocationZip":"M5G1X8",
                "LocationCountry":"Canada"
              },{
                "LocationFacility":"University of Perugia",
                "LocationCity":"Perugia",
                "LocationZip":"06132",
                "LocationCountry":"Italy"
              },{
                "LocationFacility":"Leiden University Medical Center",
                "LocationCity":"Leiden",
                "LocationZip":"2333",
                "LocationCountry":"Netherlands"
              },{
                "LocationFacility":"Maastricht University Medical Center",
                "LocationCity":"Maastricht",
                "LocationZip":"6202",
                "LocationCountry":"Netherlands"
              },{
                "LocationFacility":"Sahlgrenska University Medical Center",
                "LocationCity":"Gothenburg",
                "LocationZip":"SE-41685",
                "LocationCountry":"Sweden"
              },{
                "LocationFacility":"Karolinska University Hospital",
                "LocationCity":"Stockholm",
                "LocationZip":"14186",
                "LocationCountry":"Sweden"
              }
            ]
          }
        },
        "ReferencesModule":{
          "ReferenceList":{
            "Reference":[
              {
                "ReferenceType":"background",
                "ReferenceCitation":"American College of Obstetricians and Gynecologists. Guidelines for Perinatal Care, Sixth Edition, October 2007."
              },{
                "ReferencePMID":"21210474",
                "ReferenceType":"background",
                "ReferenceCitation":"Nicolaides KH. A model for a new pyramid of prenatal care based on the 11 to 13 weeks' assessment. Prenat Diagn. 2011 Jan;31(1):3-6. doi: 10.1002/pd.2685."
              },{
                "ReferencePMID":"16282175",
                "ReferenceType":"background",
                "ReferenceCitation":"Malone FD, Canick JA, Ball RH, Nyberg DA, Comstock CH, Bukowski R, Berkowitz RL, Gross SJ, Dugoff L, Craigo SD, Timor-Tritsch IE, Carr SR, Wolfe HM, Dukes K, Bianchi DW, Rudnicka AR, Hackshaw AK, Lambert-Messerlian G, Wald NJ, D'Alton ME; First- and Second-Trimester Evaluation of Risk (FASTER) Research Consortium. First-trimester or second-trimester screening, or both, for Down's syndrome. N Engl J Med. 2005 Nov 10;353(19):2001-11."
              },{
                "ReferencePMID":"15736186",
                "ReferenceType":"background",
                "ReferenceCitation":"Nicolaides KH, Spencer K, Avgidou K, Faiola S, Falcon O. Multicenter study of first-trimester screening for trisomy 21 in 75 821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening. Ultrasound Obstet Gynecol. 2005 Mar;25(3):221-6."
              },{
                "ReferencePMID":"15027007",
                "ReferenceType":"background",
                "ReferenceCitation":"Cicero S, Rembouskos G, Vandecruys H, Hogg M, Nicolaides KH. Likelihood ratio for trisomy 21 in fetuses with absent nasal bone at the 11-14-week scan. Ultrasound Obstet Gynecol. 2004 Mar;23(3):218-23."
              },{
                "ReferencePMID":"15386454",
                "ReferenceType":"background",
                "ReferenceCitation":"Borrell A. The ductus venosus in early pregnancy and congenital anomalies. Prenat Diagn. 2004 Sep;24(9):688-92. Review."
              },{
                "ReferencePMID":"15937972",
                "ReferenceType":"background",
                "ReferenceCitation":"Faiola S, Tsoi E, Huggon IC, Allan LD, Nicolaides KH. Likelihood ratio for trisomy 21 in fetuses with tricuspid regurgitation at the 11 to 13 + 6-week scan. Ultrasound Obstet Gynecol. 2005 Jul;26(1):22-7."
              },{
                "ReferencePMID":"17346551",
                "ReferenceType":"background",
                "ReferenceCitation":"Sonek J, Borenstein M, Dagklis T, Persico N, Nicolaides KH. Frontomaxillary facial angle in fetuses with trisomy 21 at 11-13(6) weeks. Am J Obstet Gynecol. 2007 Mar;196(3):271.e1-4."
              },{
                "ReferencePMID":"17197615",
                "ReferenceType":"background",
                "ReferenceCitation":"ACOG Committee on Practice Bulletins. ACOG Practice Bulletin No. 77: screening for fetal chromosomal abnormalities. Obstet Gynecol. 2007 Jan;109(1):217-27."
              },{
                "ReferencePMID":"18055749",
                "ReferenceType":"background",
                "ReferenceCitation":"American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 88, December 2007. Invasive prenatal testing for aneuploidy. Obstet Gynecol. 2007 Dec;110(6):1459-67."
              },{
                "ReferencePMID":"21310373",
                "ReferenceType":"background",
                "ReferenceCitation":"Ehrich M, Deciu C, Zwiefelhofer T, Tynan JA, Cagasan L, Tim R, Lu V, McCullough R, McCarthy E, Nygren AO, Dean J, Tang L, Hutchison D, Lu T, Wang H, Angkachatchai V, Oeth P, Cantor CR, Bombard A, van den Boom D. Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting. Am J Obstet Gynecol. 2011 Mar;204(3):205.e1-11. doi: 10.1016/j.ajog.2010.12.060. Epub 2011 Feb 18."
              },{
                "ReferencePMID":"9274585",
                "ReferenceType":"background",
                "ReferenceCitation":"Lo YM, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, Wainscoat JS. Presence of fetal DNA in maternal plasma and serum. Lancet. 1997 Aug 16;350(9076):485-7."
              },{
                "ReferencePMID":"18838674",
                "ReferenceType":"background",
                "ReferenceCitation":"Fan HC, Blumenfeld YJ, Chitkara U, Hudgins L, Quake SR. Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16266-71. doi: 10.1073/pnas.0808319105. Epub 2008 Oct 6."
              },{
                "ReferencePMID":"19073917",
                "ReferenceType":"background",
                "ReferenceCitation":"Chiu RW, Chan KC, Gao Y, Lau VY, Zheng W, Leung TY, Foo CH, Xie B, Tsui NB, Lun FM, Zee BC, Lau TK, Cantor CR, Lo YM. Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20458-63. doi: 10.1073/pnas.0810641105. Epub 2008 Dec 10."
              },{
                "ReferencePMID":"20026875",
                "ReferenceType":"background",
                "ReferenceCitation":"Chiu RW, Sun H, Akolekar R, Clouser C, Lee C, McKernan K, Zhou D, Nicolaides KH, Lo YM. Maternal plasma DNA analysis with massively parallel sequencing by ligation for noninvasive prenatal diagnosis of trisomy 21. Clin Chem. 2010 Mar;56(3):459-63. doi: 10.1373/clinchem.2009.136507. Epub 2009 Dec 21."
              },{
                "ReferenceType":"background",
                "ReferenceCitation":"Palomaki GE, Kloza EM, Lambert-Messerlian GM, Haddow JE, Neveux LM, Ehrich M, et al. DNA sequencing of maternal plasma to detect Down syndrome: An international clinical validation study [published online ahead of print 14 October, 2011]. Genet Med 2011. http://journals.lww.com/geneticsinmedicine/toc/publishahead. Accessed 27 October, 2011."
              },{
                "ReferencePMID":"17292767",
                "ReferenceType":"background",
                "ReferenceCitation":"Dhallan R, Guo X, Emche S, Damewood M, Bayliss P, Cronin M, Barry J, Betz J, Franz K, Gold K, Vallecillo B, Varney J. A non-invasive test for prenatal diagnosis based on fetal DNA present in maternal blood: a preliminary study. Lancet. 2007 Feb 10;369(9560):474-81."
              },{
                "ReferencePMID":"19850629",
                "ReferenceType":"background",
                "ReferenceCitation":"Tong YK, Jin S, Chiu RW, Ding C, Chan KC, Leung TY, Yu L, Lau TK, Lo YM. Noninvasive prenatal detection of trisomy 21 by an epigenetic-genetic chromosome-dosage approach. Clin Chem. 2010 Jan;56(1):90-8. doi: 10.1373/clinchem.2009.134114. Epub 2009 Oct 22."
              },{
                "ReferencePMID":"20949031",
                "ReferenceType":"background",
                "ReferenceCitation":"Ghanta S, Mitchell ME, Ames M, Hidestrand M, Simpson P, Goetsch M, Thilly WG, Struble CA, Tomita-Mitchell A. Non-invasive prenatal detection of trisomy 21 using tandem single nucleotide polymorphisms. PLoS One. 2010 Oct 8;5(10):e13184. doi: 10.1371/journal.pone.0013184."
              },{
                "ReferencePMID":"25830321",
                "ReferenceType":"derived",
                "ReferenceCitation":"Norton ME, Jacobsson B, Swamy GK, Laurent LC, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ, Wapner RJ. Cell-free DNA analysis for noninvasive examination of trisomy. N Engl J Med. 2015 Apr 23;372(17):1589-97. doi: 10.1056/NEJMoa1407349. Epub 2015 Apr 1."
              }
            ]
          },
          "SeeAlsoLinkList":{
            "SeeAlsoLink":[
              {
                "SeeAlsoLinkLabel":"Click here for more information about Ariosa Diagnostics",
                "SeeAlsoLinkURL":"http://www.ariosadx.com"
              },{
                "SeeAlsoLinkLabel":"Click here to find more information about the Perinatal Quality Foundation",
                "SeeAlsoLinkURL":"http://www.perinatalquality.com/"
              }
            ]
          }
        }
      },
      "DerivedSection":{
        "MiscInfoModule":{
          "VersionHolder":"April 22, 2020"
        },
        "ConditionBrowseModule":{
          "ConditionMeshList":{
            "ConditionMesh":[
              {
                "ConditionMeshId":"D000004314",
                "ConditionMeshTerm":"Down Syndrome"
              },{
                "ConditionMeshId":"D000014314",
                "ConditionMeshTerm":"Trisomy"
              }
            ]
          },
          "ConditionAncestorList":{
            "ConditionAncestor":[
              {
                "ConditionAncestorId":"D000000782",
                "ConditionAncestorTerm":"Aneuploidy"
              },{
                "ConditionAncestorId":"D000002869",
                "ConditionAncestorTerm":"Chromosome Aberrations"
              },{
                "ConditionAncestorId":"D000010335",
                "ConditionAncestorTerm":"Pathologic Processes"
              },{
                "ConditionAncestorId":"D000058674",
                "ConditionAncestorTerm":"Chromosome Duplication"
              },{
                "ConditionAncestorId":"D000008607",
                "ConditionAncestorTerm":"Intellectual Disability"
              },{
                "ConditionAncestorId":"D000019954",
                "ConditionAncestorTerm":"Neurobehavioral Manifestations"
              },{
                "ConditionAncestorId":"D000009461",
                "ConditionAncestorTerm":"Neurologic Manifestations"
              },{
                "ConditionAncestorId":"D000009422",
                "ConditionAncestorTerm":"Nervous System Diseases"
              },{
                "ConditionAncestorId":"D000000015",
                "ConditionAncestorTerm":"Abnormalities, Multiple"
              },{
                "ConditionAncestorId":"D000000013",
                "ConditionAncestorTerm":"Congenital Abnormalities"
              },{
                "ConditionAncestorId":"D000025063",
                "ConditionAncestorTerm":"Chromosome Disorders"
              },{
                "ConditionAncestorId":"D000030342",
                "ConditionAncestorTerm":"Genetic Diseases, Inborn"
              }
            ]
          },
          "ConditionBrowseLeafList":{
            "ConditionBrowseLeaf":[
              {
                "ConditionBrowseLeafId":"M14938",
                "ConditionBrowseLeafName":"Syndrome",
                "ConditionBrowseLeafRelevance":"low"
              },{
                "ConditionBrowseLeafId":"M6072",
                "ConditionBrowseLeafName":"Down Syndrome",
                "ConditionBrowseLeafAsFound":"Trisomy 21",
                "ConditionBrowseLeafRelevance":"high"
              },{
                "ConditionBrowseLeafId":"M2693",
                "ConditionBrowseLeafName":"Aneuploidy",
                "ConditionBrowseLeafRelevance":"low"
              },{
                "ConditionBrowseLeafId":"M15649",
                "ConditionBrowseLeafName":"Trisomy",
                "ConditionBrowseLeafAsFound":"Trisomy",
                "ConditionBrowseLeafRelevance":"high"
              },{
                "ConditionBrowseLeafId":"M21607",
                "ConditionBrowseLeafName":"Chromosome Disorders",
                "ConditionBrowseLeafRelevance":"low"
              },{
                "ConditionBrowseLeafId":"M4692",
                "ConditionBrowseLeafName":"Chromosome Aberrations",
                "ConditionBrowseLeafRelevance":"low"
              },{
                "ConditionBrowseLeafId":"M10172",
                "ConditionBrowseLeafName":"Intellectual Disability",
                "ConditionBrowseLeafRelevance":"low"
              },{
                "ConditionBrowseLeafId":"M20410",
                "ConditionBrowseLeafName":"Neurobehavioral Manifestations",
                "ConditionBrowseLeafRelevance":"low"
              },{
                "ConditionBrowseLeafId":"M10987",
                "ConditionBrowseLeafName":"Neurologic Manifestations",
                "ConditionBrowseLeafRelevance":"low"
              },{
                "ConditionBrowseLeafId":"M12",
                "ConditionBrowseLeafName":"Congenital Abnormalities",
                "ConditionBrowseLeafRelevance":"low"
              },{
                "ConditionBrowseLeafId":"M14",
                "ConditionBrowseLeafName":"Abnormalities, Multiple",
                "ConditionBrowseLeafRelevance":"low"
              },{
                "ConditionBrowseLeafId":"M22270",
                "ConditionBrowseLeafName":"Genetic Diseases, Inborn",
                "ConditionBrowseLeafRelevance":"low"
              },{
                "ConditionBrowseLeafId":"T1202",
                "ConditionBrowseLeafName":"Chromosomal Triplication",
                "ConditionBrowseLeafAsFound":"Trisomy",
                "ConditionBrowseLeafRelevance":"high"
              }
            ]
          },
          "ConditionBrowseBranchList":{
            "ConditionBrowseBranch":[
              {
                "ConditionBrowseBranchAbbrev":"BC23",
                "ConditionBrowseBranchName":"Symptoms and General Pathology"
              },{
                "ConditionBrowseBranchAbbrev":"All",
                "ConditionBrowseBranchName":"All Conditions"
              },{
                "ConditionBrowseBranchAbbrev":"BC10",
                "ConditionBrowseBranchName":"Nervous System Diseases"
              },{
                "ConditionBrowseBranchAbbrev":"BC16",
                "ConditionBrowseBranchName":"Diseases and Abnormalities at or Before Birth"
              },{
                "ConditionBrowseBranchAbbrev":"BXM",
                "ConditionBrowseBranchName":"Behaviors and Mental Disorders"
              },{
                "ConditionBrowseBranchAbbrev":"Rare",
                "ConditionBrowseBranchName":"Rare Diseases"
              }
            ]
          }
        }
      }
    }
  }
}