{ "FullStudy":{ "Rank":218215, "Study":{ "ProtocolSection":{ "IdentificationModule":{ "NCTId":"NCT01511237", "OrgStudyIdInfo":{ "OrgStudyId":"PHPT-5 Second Phase" }, "SecondaryIdInfoList":{ "SecondaryIdInfo":[ { "SecondaryId":"R01HD052461", "SecondaryIdType":"U.S. NIH Grant/Contract", "SecondaryIdLink":"https://projectreporter.nih.gov/reporterapi.cfm?PROJECTNUM=R01HD052461&Fy=all" },{ "SecondaryId":"R01HD056953", "SecondaryIdType":"U.S. NIH Grant/Contract", "SecondaryIdLink":"https://projectreporter.nih.gov/reporterapi.cfm?PROJECTNUM=R01HD056953&Fy=all" } ] }, "Organization":{ "OrgFullName":"Institut de Recherche pour le Developpement", "OrgClass":"OTHER_GOV" }, "BriefTitle":"Perinatal Antiretroviral Intensification for PMTCT of HIV in Late Comers", "OfficialTitle":"PHPT-5 Second Phase: Perinatal Antiretroviral Intensification for the Prevention of Mother-to-child Transmission of HIV in Thai Women Having Received Less Than 8 Weeks of HAART During Pregnancy", "Acronym":"PHPT-5" }, "StatusModule":{ "StatusVerifiedDate":"November 2016", "OverallStatus":"Unknown status", "LastKnownStatus":"Active, not recruiting", "ExpandedAccessInfo":{ "HasExpandedAccess":"No" }, "StartDateStruct":{ "StartDate":"December 2011" }, "PrimaryCompletionDateStruct":{ "PrimaryCompletionDate":"June 2015", "PrimaryCompletionDateType":"Actual" }, "CompletionDateStruct":{ "CompletionDate":"March 2017", "CompletionDateType":"Anticipated" }, "StudyFirstSubmitDate":"January 10, 2012", "StudyFirstSubmitQCDate":"January 12, 2012", "StudyFirstPostDateStruct":{ "StudyFirstPostDate":"January 18, 2012", "StudyFirstPostDateType":"Estimate" }, "LastUpdateSubmitDate":"November 7, 2016", "LastUpdatePostDateStruct":{ "LastUpdatePostDate":"November 8, 2016", "LastUpdatePostDateType":"Estimate" } }, "SponsorCollaboratorsModule":{ "ResponsibleParty":{ "ResponsiblePartyType":"Principal Investigator", "ResponsiblePartyInvestigatorFullName":"Marc Lallemant", "ResponsiblePartyInvestigatorTitle":"Senior Researcher", "ResponsiblePartyInvestigatorAffiliation":"Institut de Recherche pour le Developpement" }, "LeadSponsor":{ "LeadSponsorName":"Institut de Recherche pour le Developpement", "LeadSponsorClass":"OTHER_GOV" }, "CollaboratorList":{ "Collaborator":[ { "CollaboratorName":"Harvard School of Public Health", "CollaboratorClass":"OTHER" },{ "CollaboratorName":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)", "CollaboratorClass":"NIH" } ] } }, "OversightModule":{ "OversightHasDMC":"Yes" }, "DescriptionModule":{ "BriefSummary":"The purpose is to evaluate the efficacy of maternal and infant perinatal antiretroviral prophylaxis intensification for the prevention of mother-to-child intrapartum transmission of HIV-1 in women receiving less than 8 weeks of antiretroviral prophylaxis during pregnancy.", "DetailedDescription":"Design: a multicenter, phase III, single-arm trial.\n\nPerinatal antiretroviral intensification (study treatment) is defined as the addition to the standard of care* for mothers and infants of:\n\nMothers: One NVP 200 mg tablet at onset of labor with continuation of HAART for four weeks postpartum\n\nNewborn: AZT+3TC+ NVP for 2 weeks, followed by AZT+3TC for 2 weeks:\n\nNVP syrup 2 mg/kg every 24 hours for seven days, followed by NVP syrup 4 mg/kg every 24 hours for seven days. Newborns less than 2500 g will be administered 2mg/kg NVP syrup at each intake\nAZT syrup 4 mg/ kg will be given every 12 hours for four weeks (preterm infants less than 30 weeks will be administered 2 mg/kg every 12 hours; preterm 30-35 weeks will receive 2 mg/kg every 12 hours for the first 2 weeks, increased to 3 mg/kg for the next 2 weeks).\n\n3TC syrup 2 mg/kg every 12 hours for four weeks.\n\nThe standard of care in Thailand is defined as:\nMaternal antiretroviral treatment: ZDV 300 mg, 3TC 150mg and LPV/r 400/100 twice a day starting as soon possible after 14 weeks of pregnancy + ZDV 300 mg every 3 hours during labor; this treatment may be continued, stopped or modified after delivery upon the recommendation of the internist.\nNewborn: ZDV 4 mg/kg every 12 hours for 4 weeks (ZDV dosing adjusted for premature infants)." }, "ConditionsModule":{ "ConditionList":{ "Condition":[ "HIV Infections" ] }, "KeywordList":{ "Keyword":[ "HIV-1 infection", "Prophylaxis", "Mother-to-child transmission HIV-1", "Thailand", "Developing Countries" ] } }, "DesignModule":{ "StudyType":"Interventional", "PhaseList":{ "Phase":[ "Phase 3" ] }, "DesignInfo":{ "DesignInterventionModel":"Single Group Assignment", "DesignPrimaryPurpose":"Prevention", "DesignMaskingInfo":{ "DesignMasking":"None (Open Label)" } }, "EnrollmentInfo":{ "EnrollmentCount":"1837", "EnrollmentType":"Anticipated" } }, "ArmsInterventionsModule":{ "ArmGroupList":{ "ArmGroup":[ { "ArmGroupLabel":"Perinatal intensification", "ArmGroupType":"Experimental", "ArmGroupDescription":"Perinatal antiretroviral intensification (study treatment):\n\nMothers: One NVP 200 mg tablet at onset of labor with continuation of HAART for four weeks postpartum\nNewborn: AZT+3TC+ NVP for 2 weeks, followed by AZT+3TC for 2 weeks\n\nThe standard of care in Thailand is defined as:\n\nMaternal: ZDV 300 mg, 3TC 150mg and LPV/r 400/100 twice a day starting as soon possible after 14 weeks of pregnancy + ZDV 300 mg every 3 hours during labor\nNewborn: ZDV 4 mg/kg every 12 hours for 4 weeks (ZDV dosing adjusted for premature infants).", "ArmGroupInterventionList":{ "ArmGroupInterventionName":[ "Drug: Nevirapine, zidovudine, lamivudine" ] } } ] }, "InterventionList":{ "Intervention":[ { "InterventionType":"Drug", "InterventionName":"Nevirapine, zidovudine, lamivudine", "InterventionDescription":"Mothers: One NVP 200 mg tablet at onset of labor with continuation of HAART for four weeks postpartum\n\nNewborn: AZT+3TC+ NVP for 2 weeks, followed by AZT+3TC for 2 weeks:\n\nNVP syrup 2 mg/kg every 24 hours for seven days, followed by NVP syrup 4 mg/kg every 24 hours for seven days. Newborns less than 2500 g will be administered 2mg/kg NVP syrup at each intake\nAZT syrup 4 mg/ kg will be given every 12 hours for four weeks (preterm infants less than 30 weeks will be administered 2 mg/kg every 12 hours; preterm 30-35 weeks will receive 2 mg/kg every 12 hours for the first 2 weeks, increased to 3 mg/kg for the next 2 weeks).\n3TC syrup 2 mg/kg every 12 hours for four weeks.", "InterventionArmGroupLabelList":{ "InterventionArmGroupLabel":[ "Perinatal intensification" ] } } ] } }, "OutcomesModule":{ "PrimaryOutcomeList":{ "PrimaryOutcome":[ { "PrimaryOutcomeMeasure":"Rate of perinatal HIV transmission", "PrimaryOutcomeDescription":"HIV DNA PCR analysis at birth, 2 weeks, 1, 2, 4 and 6 months of age", "PrimaryOutcomeTimeFrame":"6 months" } ] }, "SecondaryOutcomeList":{ "SecondaryOutcome":[ { "SecondaryOutcomeMeasure":"Safety for women and neonates", "SecondaryOutcomeDescription":"All grade 3 and 4 clinical adverse events and abnormal laboratory values in women will be recorded and graded according to the toxicity tables developed by the DAIDS", "SecondaryOutcomeTimeFrame":"Up to 12 Months" },{ "SecondaryOutcomeMeasure":"Pregnancy outcomes", "SecondaryOutcomeDescription":"Evaluation of the rates of live births and stillbirths, as well as birth weight, gestational age at delivery according to the results of the sonogram at first prenatal visit, newborn maturity (Ballard score).", "SecondaryOutcomeTimeFrame":"Up to 12 Months" } ] } }, "EligibilityModule":{ "EligibilityCriteria":"Eligibility. Pregnant women presenting at the prenatal clinics will be eligible if they are confirmed HIV-infected, intend to deliver and bring their infant to a study site for postnatal care for at least 6 months; at least 18 years old; and have given written informed consent to participate in the study, regardless of their CD4 cell count.\n\nMaternal inclusion criteria:\n\nEvidence of HIV infection, as documented by two serology tests obtained at two different dates;\n\nAll HIV infected pregnant women will be enrolled, either in the intervention arm or an observational study group.\n\nWomen more than 30 weeks gestational age at start of antiretroviral treatment will be eligible for the intervention. They will actually receive the study intervention if they present in labor after less than 8 weeks of treatment duration;\nWomen with no ANC will receive standard care and will be enrolled in an observational study group(and their infant will receive standard of care perinatal antiretroviral intensification)\nWomen with less than 30 weeks gestational age at start of treatment will receive standard care and will also be enrolled in the Observational Reference group;\nAgreement not to breastfeed;\nConsent to participate and to be followed for the duration of the study\n\nExclusion Criteria:\n\nEvidence of pre-existing fetal anomalies incompatible with life;\nConcurrent participation to any other clinical trial without prior agreement of the two study teams", "HealthyVolunteers":"No", "Gender":"Female", "MinimumAge":"18 Years", "StdAgeList":{ "StdAge":[ "Adult", "Older Adult" ] } }, "ContactsLocationsModule":{ "OverallOfficialList":{ "OverallOfficial":[ { "OverallOfficialName":"Marc Lallemant, MD", "OverallOfficialAffiliation":"Institut de Recherche pour le Developpment", "OverallOfficialRole":"Principal Investigator" } ] }, "LocationList":{ "Location":[ { "LocationFacility":"Health Promotion Hospital Regional Center I", "LocationCity":"Bangkean", "LocationState":"Bangkok", "LocationZip":"10220", "LocationCountry":"Thailand" },{ "LocationFacility":"Nopparat Rajathanee Hospital", "LocationCity":"Kannayao", "LocationState":"Bangkok", "LocationZip":"10230", "LocationCountry":"Thailand" },{ "LocationFacility":"Bhumibol Adulyadej Hospital", "LocationCity":"Saimai", "LocationState":"Bangkok", "LocationZip":"10220", "LocationCountry":"Thailand" },{ "LocationFacility":"Bhuddasothorn Hospital", "LocationCity":"Muang", "LocationState":"Chachoengsao", "LocationZip":"24000", "LocationCountry":"Thailand" },{ "LocationFacility":"Prapokklao Hospital", "LocationCity":"Muang", "LocationState":"Chantaburi", "LocationZip":"22000", "LocationCountry":"Thailand" },{ "LocationFacility":"Chomthong Hospital", "LocationCity":"Chomthong", "LocationState":"Chiang Mai", "LocationZip":"50160", "LocationCountry":"Thailand" },{ "LocationFacility":"Fang Hospital", "LocationCity":"Fang", "LocationState":"Chiang Mai", "LocationZip":"50110", "LocationCountry":"Thailand" },{ "LocationFacility":"Nakornping Hospital", "LocationCity":"Mae Rim", "LocationState":"Chiang Mai", "LocationZip":"50180", "LocationCountry":"Thailand" },{ "LocationFacility":"Health Promotion Center Region 10, Chiang Mai", "LocationCity":"Muang", "LocationState":"Chiang Mai", "LocationZip":"50100", "LocationCountry":"Thailand" },{ "LocationFacility":"Sanpatong Hospital", "LocationCity":"Sanpatong", "LocationState":"Chiang Mai", "LocationZip":"50120", "LocationCountry":"Thailand" },{ "LocationFacility":"Mae Chan Hospital", "LocationCity":"Mae Chan", "LocationState":"Chiang Rai", "LocationZip":"57110", "LocationCountry":"Thailand" },{ "LocationFacility":"Mae Sai Hospital", "LocationCity":"Mae Sai", "LocationState":"Chiang Rai", "LocationZip":"57130", "LocationCountry":"Thailand" },{ "LocationFacility":"Phan Hospital", "LocationCity":"Phan", "LocationState":"Chiang Rai", "LocationZip":"57120", "LocationCountry":"Thailand" },{ "LocationFacility":"Chiang Saen Hospital", "LocationCity":"Chiang Saen", "LocationState":"Chiangrai", "LocationZip":"57150", "LocationCountry":"Thailand" },{ "LocationFacility":"Chiangrai Prachanukroh Hospital", "LocationCity":"Muang", "LocationState":"Chiangrai", "LocationZip":"57000", "LocationCountry":"Thailand" },{ "LocationFacility":"Wiangpapao Hospital", "LocationCity":"Wiangpapao", "LocationState":"Chiangrai", "LocationZip":"57170", "LocationCountry":"Thailand" },{ "LocationFacility":"Banglamung Hospital", "LocationCity":"Banglamung", "LocationState":"Chonburi", "LocationZip":"20150", "LocationCountry":"Thailand" },{ "LocationFacility":"Chonburi Hospital", "LocationCity":"Muang", "LocationState":"Chonburi", "LocationZip":"20000", "LocationCountry":"Thailand" },{ "LocationFacility":"Panasnikom Hospital", "LocationCity":"Panasnikom", "LocationState":"Chonburi", "LocationZip":"20140", "LocationCountry":"Thailand" },{ "LocationFacility":"Kalasin Hospital", "LocationCity":"Muang", "LocationState":"Kalasin", "LocationZip":"46000", "LocationCountry":"Thailand" },{ "LocationFacility":"Khon Kaen Hospital", "LocationCity":"Muang", "LocationState":"Khon Kaen", "LocationZip":"40000", "LocationCountry":"Thailand" },{ "LocationFacility":"Regional Health Promotion Centre 6, Khon Kaen", "LocationCity":"Muang", "LocationState":"Khon Kaen", "LocationZip":"40000", "LocationCountry":"Thailand" },{ "LocationFacility":"Lampang Hospital", "LocationCity":"Muang", "LocationState":"Lampang", "LocationZip":"52000", "LocationCountry":"Thailand" },{ "LocationFacility":"Lamphun Hospital", "LocationCity":"Muang", "LocationState":"Lamphun", "LocationZip":"51000", "LocationCountry":"Thailand" },{ "LocationFacility":"Mahasarakam Hospital", "LocationCity":"Muang", "LocationState":"Mahasarakam", "LocationZip":"44000", "LocationCountry":"Thailand" },{ "LocationFacility":"Maharaj Nakhon Si Thammarat Hospital", "LocationCity":"Muang", "LocationState":"Nakhon Si Thammarat", "LocationZip":"80000", "LocationCountry":"Thailand" },{ "LocationFacility":"Nakhonpathom Hospital", "LocationCity":"Muang", "LocationState":"Nakhonpathom", "LocationZip":"73000", "LocationCountry":"Thailand" },{ "LocationFacility":"Nong Khai Hospital", "LocationCity":"Muang", "LocationState":"Nong Khai", "LocationZip":"43000", "LocationCountry":"Thailand" },{ "LocationFacility":"Pranangklao Hospital", "LocationCity":"Muang", "LocationState":"Nonthaburi", "LocationZip":"11000", "LocationCountry":"Thailand" },{ "LocationFacility":"Chiang Kham Hospital", "LocationCity":"Chiang Kham", "LocationState":"Phayao", "LocationZip":"56110", "LocationCountry":"Thailand" },{ "LocationFacility":"Phayao Provincial Hospital", "LocationCity":"Muang", "LocationState":"Phayao", "LocationZip":"56000", "LocationCountry":"Thailand" },{ "LocationFacility":"Vachira Phuket Hospital", "LocationCity":"Muang", "LocationState":"Phuket", "LocationZip":"83000", "LocationCountry":"Thailand" },{ "LocationFacility":"Buddhachinaraj Hospital", "LocationCity":"Muang", "LocationState":"Pitsanuloke", "LocationZip":"65000", "LocationCountry":"Thailand" },{ "LocationFacility":"Rayong Hospital", "LocationCity":"Muang", "LocationState":"Rayong", "LocationZip":"21000", "LocationCountry":"Thailand" },{ "LocationFacility":"Samutprakarn Hospital", "LocationCity":"Muang", "LocationState":"Samutprakarn", "LocationZip":"10280", "LocationCountry":"Thailand" },{ "LocationFacility":"Samutsakhon Hospital", "LocationCity":"Muang", "LocationState":"Samutsakhon", "LocationZip":"74000", "LocationCountry":"Thailand" },{ "LocationFacility":"Songkhla Hospital", "LocationCity":"Muangsongkhla", "LocationState":"Songkhla", "LocationZip":"90100", "LocationCountry":"Thailand" },{ "LocationFacility":"Hat Yai Hospital", "LocationCity":"Hat Yai", "LocationState":"Songkla", "LocationZip":"90110", "LocationCountry":"Thailand" } ] } }, "ReferencesModule":{ "ReferenceList":{ "Reference":[ { "ReferenceType":"result", "ReferenceCitation":"Lallemant Marc, Amzal Billy, Urien Saik, Sripan Patumrat, Cressey Tim R, Ngo-Giang-Huong Nicole, Rawangban Boonsong, Sabsanong Prapan, Siriwachirachai Thitiporn, Jarupanich Tapnarong, Kanjanavikai Prateep, Wanasiri Phaiboon, Koetsawang Suporn, Jourdain Gonzague, Le Cœur Sophie, for the PHPT-5 team. 2015. -\"Antiretroviral Intensification to Prevent Intrapartum HIV Transmission in Late Comers\". 8th IAS Conference on HIV Pathogenesis Treatment & Prevention, Vancouver, Canada, 19-22 July 2015." } ] }, "SeeAlsoLinkList":{ "SeeAlsoLink":[ { "SeeAlsoLinkLabel":"PHPT-5 First Phase", "SeeAlsoLinkURL":"http://www.clinicaltrials.gov/ct2/show/NCT00409591" } ] } } }, "DerivedSection":{ "MiscInfoModule":{ "VersionHolder":"April 22, 2020" }, "InterventionBrowseModule":{ "InterventionMeshList":{ "InterventionMesh":[ { "InterventionMeshId":"D000019259", "InterventionMeshTerm":"Lamivudine" },{ "InterventionMeshId":"D000015215", "InterventionMeshTerm":"Zidovudine" },{ "InterventionMeshId":"D000019829", "InterventionMeshTerm":"Nevirapine" } ] }, "InterventionAncestorList":{ "InterventionAncestor":[ { "InterventionAncestorId":"D000018894", "InterventionAncestorTerm":"Reverse Transcriptase Inhibitors" },{ "InterventionAncestorId":"D000019384", "InterventionAncestorTerm":"Nucleic Acid Synthesis Inhibitors" },{ "InterventionAncestorId":"D000004791", "InterventionAncestorTerm":"Enzyme Inhibitors" },{ "InterventionAncestorId":"D000045504", "InterventionAncestorTerm":"Molecular Mechanisms of Pharmacological Action" },{ "InterventionAncestorId":"D000044966", "InterventionAncestorTerm":"Anti-Retroviral Agents" },{ "InterventionAncestorId":"D000000998", "InterventionAncestorTerm":"Antiviral Agents" },{ "InterventionAncestorId":"D000000890", "InterventionAncestorTerm":"Anti-Infective Agents" },{ "InterventionAncestorId":"D000019380", "InterventionAncestorTerm":"Anti-HIV Agents" },{ "InterventionAncestorId":"D000000963", "InterventionAncestorTerm":"Antimetabolites" },{ "InterventionAncestorId":"D000065701", "InterventionAncestorTerm":"Cytochrome P-450 CYP3A Inducers" },{ "InterventionAncestorId":"D000065693", "InterventionAncestorTerm":"Cytochrome P-450 Enzyme Inducers" } ] }, "InterventionBrowseLeafList":{ "InterventionBrowseLeaf":[ { "InterventionBrowseLeafId":"M19827", "InterventionBrowseLeafName":"Lamivudine", "InterventionBrowseLeafAsFound":"Lamivudine", "InterventionBrowseLeafRelevance":"high" },{ "InterventionBrowseLeafId":"M16503", "InterventionBrowseLeafName":"Zidovudine", "InterventionBrowseLeafAsFound":"Zidovudine", "InterventionBrowseLeafRelevance":"high" },{ "InterventionBrowseLeafId":"M20301", "InterventionBrowseLeafName":"Nevirapine", "InterventionBrowseLeafAsFound":"Nevirapine", "InterventionBrowseLeafRelevance":"high" },{ "InterventionBrowseLeafId":"M19519", "InterventionBrowseLeafName":"Reverse Transcriptase Inhibitors", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M24015", "InterventionBrowseLeafName":"Anti-Retroviral Agents", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M2895", "InterventionBrowseLeafName":"Antiviral Agents", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M2795", "InterventionBrowseLeafName":"Anti-Infective Agents", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M19934", "InterventionBrowseLeafName":"Anti-HIV Agents", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M2862", "InterventionBrowseLeafName":"Antimetabolites", "InterventionBrowseLeafRelevance":"low" } ] }, "InterventionBrowseBranchList":{ "InterventionBrowseBranch":[ { "InterventionBrowseBranchAbbrev":"Infe", "InterventionBrowseBranchName":"Anti-Infective Agents" },{ "InterventionBrowseBranchAbbrev":"All", "InterventionBrowseBranchName":"All Drugs and Chemicals" } ] } }, "ConditionBrowseModule":{ "ConditionMeshList":{ "ConditionMesh":[ { "ConditionMeshId":"D000007239", "ConditionMeshTerm":"Infection" },{ "ConditionMeshId":"D000015658", "ConditionMeshTerm":"HIV Infections" } ] }, "ConditionAncestorList":{ "ConditionAncestor":[ { "ConditionAncestorId":"D000016180", "ConditionAncestorTerm":"Lentivirus Infections" },{ "ConditionAncestorId":"D000012192", "ConditionAncestorTerm":"Retroviridae Infections" },{ "ConditionAncestorId":"D000012327", "ConditionAncestorTerm":"RNA Virus Infections" },{ "ConditionAncestorId":"D000014777", "ConditionAncestorTerm":"Virus Diseases" },{ "ConditionAncestorId":"D000015229", "ConditionAncestorTerm":"Sexually Transmitted Diseases, Viral" },{ "ConditionAncestorId":"D000012749", "ConditionAncestorTerm":"Sexually Transmitted Diseases" },{ "ConditionAncestorId":"D000007153", "ConditionAncestorTerm":"Immunologic Deficiency Syndromes" },{ "ConditionAncestorId":"D000007154", "ConditionAncestorTerm":"Immune System Diseases" } ] }, "ConditionBrowseLeafList":{ "ConditionBrowseLeaf":[ { "ConditionBrowseLeafId":"M8866", "ConditionBrowseLeafName":"Infection", "ConditionBrowseLeafAsFound":"Infection", "ConditionBrowseLeafRelevance":"high" },{ "ConditionBrowseLeafId":"M4951", "ConditionBrowseLeafName":"Communicable Diseases", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M16833", "ConditionBrowseLeafName":"HIV Infections", "ConditionBrowseLeafAsFound":"HIV Infections", "ConditionBrowseLeafRelevance":"high" },{ "ConditionBrowseLeafId":"M2103", "ConditionBrowseLeafName":"Acquired Immunodeficiency Syndrome", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M17223", "ConditionBrowseLeafName":"Lentivirus Infections", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M13609", "ConditionBrowseLeafName":"Retroviridae Infections", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M16105", "ConditionBrowseLeafName":"Virus Diseases", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M13732", "ConditionBrowseLeafName":"RNA Virus Infections", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M14141", "ConditionBrowseLeafName":"Sexually Transmitted Diseases", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M16516", "ConditionBrowseLeafName":"Sexually Transmitted Diseases, Viral", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M14938", "ConditionBrowseLeafName":"Syndrome", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M8782", "ConditionBrowseLeafName":"Immunologic Deficiency Syndromes", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M8783", "ConditionBrowseLeafName":"Immune System Diseases", "ConditionBrowseLeafRelevance":"low" } ] }, "ConditionBrowseBranchList":{ "ConditionBrowseBranch":[ { "ConditionBrowseBranchAbbrev":"BC01", "ConditionBrowseBranchName":"Bacterial and Fungal Diseases" },{ "ConditionBrowseBranchAbbrev":"All", "ConditionBrowseBranchName":"All Conditions" },{ "ConditionBrowseBranchAbbrev":"BC02", "ConditionBrowseBranchName":"Viral Diseases" },{ "ConditionBrowseBranchAbbrev":"BC20", "ConditionBrowseBranchName":"Immune System Diseases" },{ "ConditionBrowseBranchAbbrev":"BXS", "ConditionBrowseBranchName":"Urinary Tract, Sexual Organs, and Pregnancy Conditions" },{ "ConditionBrowseBranchAbbrev":"BC23", "ConditionBrowseBranchName":"Symptoms and General Pathology" } ] } } } } } }