{ "FullStudy":{ "Rank":218230, "Study":{ "ProtocolSection":{ "IdentificationModule":{ "NCTId":"NCT01511042", "OrgStudyIdInfo":{ "OrgStudyId":"1999P001983" }, "Organization":{ "OrgFullName":"Brigham and Women's Hospital", "OrgClass":"OTHER" }, "BriefTitle":"Vascular Dysfunction in Diabetes: Genes and Hormones", "OfficialTitle":"Non-Modulation Phenotype and Vascular Dysfunction in Diabetes Mellitus" }, "StatusModule":{ "StatusVerifiedDate":"February 2019", "OverallStatus":"Active, not recruiting", "ExpandedAccessInfo":{ "HasExpandedAccess":"No" }, "StartDateStruct":{ "StartDate":"December 1999", "StartDateType":"Actual" }, "PrimaryCompletionDateStruct":{ "PrimaryCompletionDate":"January 2020", "PrimaryCompletionDateType":"Anticipated" }, "CompletionDateStruct":{ "CompletionDate":"June 2020", "CompletionDateType":"Anticipated" }, "StudyFirstSubmitDate":"July 19, 2011", "StudyFirstSubmitQCDate":"January 12, 2012", "StudyFirstPostDateStruct":{ "StudyFirstPostDate":"January 18, 2012", "StudyFirstPostDateType":"Estimate" }, "LastUpdateSubmitDate":"February 15, 2019", "LastUpdatePostDateStruct":{ "LastUpdatePostDate":"February 18, 2019", "LastUpdatePostDateType":"Actual" } }, "SponsorCollaboratorsModule":{ "ResponsibleParty":{ "ResponsiblePartyType":"Principal Investigator", "ResponsiblePartyInvestigatorFullName":"Gordon H. Williams, MD", "ResponsiblePartyInvestigatorTitle":"Chief, Cardiovascular Endocrinology Section", "ResponsiblePartyInvestigatorAffiliation":"Brigham and Women's Hospital" }, "LeadSponsor":{ "LeadSponsorName":"Brigham and Women's Hospital", "LeadSponsorClass":"OTHER" } }, "OversightModule":{ "OversightHasDMC":"Yes" }, "DescriptionModule":{ "BriefSummary":"The investigators are very excited that the National Institutes of Health are sponsoring us to investigate why patients with diabetes are more likely to develop high blood pressure, atherosclerosis (hardening of the arteries), and heart disease. There are two parts of our research program. The first part is a screening visit. At this visit you will be given a brief physical exam and will be asked questions concerning your medical history. During the same visit you will have your blood drawn for routine screening and to prepare DNA for genetic testing. You will also be asked to collect a urine sample for routine screening.\n\nIf the doctor finds that you are a healthy candidate you will be invited to participate in the second part of the study. During Phase II the investigators will perform physiologic tests after you are placed on a low salt diet and again after you are placed on a high salt diet. All of the food that you will eat during the two diets will be provided to you by the hospital. If you are on blood pressure medication, it may be necessary to discontinue taking your present medication for up to three months before beginning the study. Patients discontinuing their current blood pressure medication may be placed on a different blood pressure medication during this washout period if necessary to maintain blood pressure at pre-study levels. The investigators will take you off all medications, except cholesterol medications two weeks prior to your scheduled in-patient study. However, if you are currently on medication to control your diabetes you will remain on this throughout the entire study.\n\nOnce your blood pressure medications are discontinued, you will be closely monitored to make sure you do not encounter any difficulty. If you do not own a home blood pressure monitor, the investigators will provide one for to use during the study so that you can keep a daily record of your blood pressure readings. The investigators will ask you to call us every three days to report your blood pressure readings. Less than 20% of patients with hypertension have any significant increase in their blood pressure during this short time off therapy. After you have been off your medication for nine days the dieticians will give you low salt meals to eat at home for six days. On the sixth day of the low salt diet, you will be asked to begin a 24-hour urine collection. You will also be required to come to the Ambulatory Clinical Center (221 Longwood Ave.) for a one-hour test. You will return that evening to the inpatient Clinical Research Center where you will be admitted for your first study that will occur the next morning. On the morning of your low salt study you will have three naturally occurring hormones administered and blood samples drawn from an intravenous needle. The investigators will also take ultrasound pictures of your heart to see how salt and hormones affect the way the heart functions. These tests will last approximately five hours and you will be discharged around 12:00 p.m. The dieticians will then give you your meals for the next week to take home. Each of these meals will have a high salt content. After six days of your high salt diet, on the morning of your second admission to the hospital, you will be asked to begin a final 24-hour urine collection. The same study that was done for the low salt study will be repeated for the high salt study. You will be discharged around 3:00 p.m. This study will determine if you are salt-sensitive. A high salt diet has been found to lead to higher blood pressure and weight gain. In addition, the investigators hope to learn more about the hormones that regulate your blood pressure and the genes responsible for regulating those hormones.\n\nYou will be placed back on your initial blood pressure medication (if you are on any) and returned to your regular physician for care. The investigators will provide clinically relevant information to you and your physician." }, "ConditionsModule":{ "ConditionList":{ "Condition":[ "Diabetes Mellitus" ] } }, "DesignModule":{ "StudyType":"Observational", "PatientRegistry":"Yes", "TargetDuration":"20 Years", "DesignInfo":{ "DesignObservationalModelList":{ "DesignObservationalModel":[ "Cohort" ] }, "DesignTimePerspectiveList":{ "DesignTimePerspective":[ "Cross-Sectional" ] } }, "BioSpec":{ "BioSpecRetention":"Samples With DNA", "BioSpecDescription":"Urine, blood, DNA" }, "EnrollmentInfo":{ "EnrollmentCount":"200", "EnrollmentType":"Anticipated" } }, "ArmsInterventionsModule":{ "InterventionList":{ "Intervention":[ { "InterventionType":"Drug", "InterventionName":"Para-aminohippuric Acid", "InterventionDescription":"Aminohippurate sodium is an agent to measure effective renal plasma flow (ERPF). It is the sodium salt of para-aminohippuric acid, commonly abbreviated \"PAH\".", "InterventionOtherNameList":{ "InterventionOtherName":[ "PAH" ] } },{ "InterventionType":"Drug", "InterventionName":"Angiotensin II", "InterventionDescription":"Angiotensin II (Ang II) is a naturally occurring hormone whose primary purpose is to regulate the body's internal volume. It accomplishes this task by influencing the function of a variety of organs and tissues. It increases aldosterone secretion from the adrenal gland. It causes blood vessels to contract, particularly renal blood vessels, and it modifies the way the heart works.", "InterventionOtherNameList":{ "InterventionOtherName":[ "AngII", "AII" ] } },{ "InterventionType":"Drug", "InterventionName":"Norepinephrine", "InterventionDescription":"A hormone that is normally present in your body, which regulates your blood pressure.", "InterventionOtherNameList":{ "InterventionOtherName":[ "NE" ] } } ] } }, "OutcomesModule":{ "PrimaryOutcomeList":{ "PrimaryOutcome":[ { "PrimaryOutcomeMeasure":"Frequency of Intermediate Phenotypes in Subjects with Diabetes Mellitus versus Hypertension", "PrimaryOutcomeDescription":"The frequency of salt sensitive blood pressure", "PrimaryOutcomeTimeFrame":"10 Years" } ] }, "SecondaryOutcomeList":{ "SecondaryOutcome":[ { "SecondaryOutcomeMeasure":"Frequency of polymorphic variants in AGT gene in Hypertensives versus diabetics", "SecondaryOutcomeDescription":"The frequency of polymorphisms in the angiotensinogen (AGT), ACE and ALDO synthase and ALAP genes in non-modulating hypertension subset.", "SecondaryOutcomeTimeFrame":"10 Years" },{ "SecondaryOutcomeMeasure":"Frequency of salt sensitive subtype in Diabetics versus hypertensives", "SecondaryOutcomeDescription":"Frequency of non-modulating phenotype and low renin phenotype in the salt sensitive subjects.subjects.", "SecondaryOutcomeTimeFrame":"10 years" } ] } }, "EligibilityModule":{ "EligibilityCriteria":"Inclusion Criteria:\n\nType II Diabetes Mellitus\nAge between 18-65 years\nBMI < 40\nIn overall good health\n\nExclusion Criteria:\n\nHistory of coronary atherosclerotic disease, MI, CVA, or significant peripheral vascular disease\nBMI > 40\nSubjects with diastolic blood pressures greater than 100 mm Hg while on anti-hypertensive medications, or systolic blood pressures greater than 160 mm Hg while on anti-hypertensive medications will be excluded.\nCurrent alcohol or drug abuse\nSubjects taking other medications (except thyroid supplements, oral hyperglycemic agents and insulin) will be excluded\nSubjects who are on medications that cannot be discontinued such as anti-depressants, anti-seizure medications, etc that may interfere with salt and water handling will not be studied.", "HealthyVolunteers":"No", "Gender":"All", "MinimumAge":"18 Years", "MaximumAge":"65 Years", "StdAgeList":{ "StdAge":[ "Adult", "Older Adult" ] }, "StudyPopulation":"Type II Diabetes Mellitus\nAge between 18-65 years\nBMI < 40\nIn overall good health", "SamplingMethod":"Non-Probability Sample" }, "ContactsLocationsModule":{ "OverallOfficialList":{ "OverallOfficial":[ { "OverallOfficialName":"Gordon H Williams, MD", "OverallOfficialAffiliation":"Brigham and Women's Hospital", "OverallOfficialRole":"Principal Investigator" } ] }, "LocationList":{ "Location":[ { "LocationFacility":"Brigham and Women's Hospital- 221 Longwood Avenue", "LocationCity":"Boston", "LocationState":"Massachusetts", "LocationZip":"02115", "LocationCountry":"United States" } ] } } }, "DerivedSection":{ "MiscInfoModule":{ "VersionHolder":"April 22, 2020" }, "InterventionBrowseModule":{ "InterventionMeshList":{ "InterventionMesh":[ { "InterventionMeshId":"D000009638", "InterventionMeshTerm":"Norepinephrine" },{ "InterventionMeshId":"D000000804", "InterventionMeshTerm":"Angiotensin II" },{ "InterventionMeshId":"C000627694", "InterventionMeshTerm":"Giapreza" },{ "InterventionMeshId":"D000000808", "InterventionMeshTerm":"Angiotensinogen" } ] }, "InterventionAncestorList":{ "InterventionAncestor":[ { "InterventionAncestorId":"D000000316", "InterventionAncestorTerm":"Adrenergic alpha-Agonists" },{ "InterventionAncestorId":"D000000322", "InterventionAncestorTerm":"Adrenergic Agonists" },{ "InterventionAncestorId":"D000018663", "InterventionAncestorTerm":"Adrenergic Agents" },{ "InterventionAncestorId":"D000018377", "InterventionAncestorTerm":"Neurotransmitter Agents" },{ "InterventionAncestorId":"D000045504", "InterventionAncestorTerm":"Molecular Mechanisms of Pharmacological Action" },{ "InterventionAncestorId":"D000045505", "InterventionAncestorTerm":"Physiological Effects of Drugs" },{ "InterventionAncestorId":"D000013566", "InterventionAncestorTerm":"Sympathomimetics" },{ "InterventionAncestorId":"D000001337", "InterventionAncestorTerm":"Autonomic Agents" },{ "InterventionAncestorId":"D000018373", "InterventionAncestorTerm":"Peripheral Nervous System Agents" },{ "InterventionAncestorId":"D000014662", "InterventionAncestorTerm":"Vasoconstrictor Agents" },{ "InterventionAncestorId":"D000015842", "InterventionAncestorTerm":"Serine Proteinase Inhibitors" },{ "InterventionAncestorId":"D000011480", "InterventionAncestorTerm":"Protease Inhibitors" },{ "InterventionAncestorId":"D000004791", "InterventionAncestorTerm":"Enzyme Inhibitors" } ] }, "InterventionBrowseLeafList":{ "InterventionBrowseLeaf":[ { "InterventionBrowseLeafId":"M2713", "InterventionBrowseLeafName":"Angiotensin II", "InterventionBrowseLeafAsFound":"Angiotensin II", "InterventionBrowseLeafRelevance":"high" },{ "InterventionBrowseLeafId":"M269574", "InterventionBrowseLeafName":"Giapreza", "InterventionBrowseLeafAsFound":"Angiotensin II", "InterventionBrowseLeafRelevance":"high" },{ "InterventionBrowseLeafId":"M2716", "InterventionBrowseLeafName":"Angiotensinogen", "InterventionBrowseLeafAsFound":"Angiotensin II", "InterventionBrowseLeafRelevance":"high" },{ "InterventionBrowseLeafId":"M11158", "InterventionBrowseLeafName":"Norepinephrine", "InterventionBrowseLeafAsFound":"Norepinephrine", "InterventionBrowseLeafRelevance":"high" },{ "InterventionBrowseLeafId":"M19330", "InterventionBrowseLeafName":"Adrenergic Agents", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M2249", "InterventionBrowseLeafName":"Adrenergic alpha-Agonists", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M2254", "InterventionBrowseLeafName":"Adrenergic Agonists", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M19088", "InterventionBrowseLeafName":"Neurotransmitter Agents", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M14928", "InterventionBrowseLeafName":"Sympathomimetics", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M15992", "InterventionBrowseLeafName":"Vasoconstrictor Agents", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M12926", "InterventionBrowseLeafName":"Protease Inhibitors", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M16974", "InterventionBrowseLeafName":"Serine Proteinase Inhibitors", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"M18192", "InterventionBrowseLeafName":"HIV Protease Inhibitors", "InterventionBrowseLeafRelevance":"low" },{ "InterventionBrowseLeafId":"T18", "InterventionBrowseLeafName":"Serine", "InterventionBrowseLeafRelevance":"low" } ] }, "InterventionBrowseBranchList":{ "InterventionBrowseBranch":[ { "InterventionBrowseBranchAbbrev":"VaCoAg", "InterventionBrowseBranchName":"Vasoconstrictor Agents" },{ "InterventionBrowseBranchAbbrev":"All", "InterventionBrowseBranchName":"All Drugs and Chemicals" },{ "InterventionBrowseBranchAbbrev":"Infe", "InterventionBrowseBranchName":"Anti-Infective Agents" },{ "InterventionBrowseBranchAbbrev":"AA", "InterventionBrowseBranchName":"Amino Acids" } ] } }, "ConditionBrowseModule":{ "ConditionMeshList":{ "ConditionMesh":[ { "ConditionMeshId":"D000003920", "ConditionMeshTerm":"Diabetes Mellitus" } ] }, "ConditionAncestorList":{ "ConditionAncestor":[ { "ConditionAncestorId":"D000044882", "ConditionAncestorTerm":"Glucose Metabolism Disorders" },{ "ConditionAncestorId":"D000008659", "ConditionAncestorTerm":"Metabolic Diseases" },{ "ConditionAncestorId":"D000004700", "ConditionAncestorTerm":"Endocrine System Diseases" } ] }, "ConditionBrowseLeafList":{ "ConditionBrowseLeaf":[ { "ConditionBrowseLeafId":"M5698", "ConditionBrowseLeafName":"Diabetes Mellitus", "ConditionBrowseLeafAsFound":"Diabetes Mellitus", "ConditionBrowseLeafRelevance":"high" },{ "ConditionBrowseLeafId":"M10222", "ConditionBrowseLeafName":"Metabolic Diseases", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M23990", "ConditionBrowseLeafName":"Glucose Metabolism Disorders", "ConditionBrowseLeafRelevance":"low" },{ "ConditionBrowseLeafId":"M6445", "ConditionBrowseLeafName":"Endocrine System Diseases", "ConditionBrowseLeafRelevance":"low" } ] }, "ConditionBrowseBranchList":{ "ConditionBrowseBranch":[ { "ConditionBrowseBranchAbbrev":"BC18", "ConditionBrowseBranchName":"Nutritional and Metabolic Diseases" },{ "ConditionBrowseBranchAbbrev":"BC19", "ConditionBrowseBranchName":"Gland and Hormone Related Diseases" },{ "ConditionBrowseBranchAbbrev":"All", "ConditionBrowseBranchName":"All Conditions" } ] } } } } } }